Matrix Metalloproteinases, matrixins
MMP14 seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.
Diseases associated with MMP14 include Winchester Syndrome and Multicentric Osteolysis, Nodulosis, And Arthropathy. Among its related pathways are Signaling events mediated by focal adhesion kinase and Adhesion
Investigation of MT1-MMP; Generation of active MT1-MMP for progelatinase A activation; Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard
Membrane-Type-1 Matrix Metalloproteinase
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2.
> 80 %
matrix metallopeptidase 14
Recombinant soluble pro-MT1-MMP is produced as a periplasmic protein in E. coli. The protein contains prodomain, catalytic domain and hemopexin domain of MT1-MMP
Mentioned in the data sheet
See the data sheet
For Research Use only.
Store at -70°C
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Recombinants or rec. proteins