Matrix Metalloproteinases, matrixins
MMP16 is a endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
Diseases associated with MMP16 include Osteochondrosis. Among its related pathways are Matrix Metalloproteinases and MicroRNAs in cancer.
Activation of progelatinase A; Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard
Membrane-Type 3 Matrix Metalloproteinase
L T G R K W Q H K H I T Y S I K N V T P K V G D P E T R K A I R R A F D V W Q N V T P L T F E E V P Y S E L E N G K R D V D I T I I F A S G F H G D S S P F D G E G G F L A H A Y F P G P G I G G D T H F D S D E P W T L G N P N H D G N D L F L V A V H E L G H A L G L E H S N D P T A I M A P F Y Q Y M E T D N F K L P N D D L Q G I Q K I Y G P P D K I P P P T R P L P T V P P H R
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 1 % glycerin, 0.1 % Triton X-100.
matrix metallopeptidase 16 (partial)
The catalytic domain of MT3-MMP is produced by activation of a recombinant soluble proform of MT3-MMP purified from E. coli.
Mentioned in the data sheet
See the data sheet
For Research Use only.
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Recombinants or rec. proteins