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MMP 16 (MT3-MMP) catalytic domain (Recombinant Protein)
from  biotez
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30 100 302 Catalog number

10 µg/ 50µl Size

340 € Price

More details

Protein type

Recombinant

Protein subtype

EC 3.4.24.80

Protein family

Matrix Metalloproteinases, matrixins

Protein description

MMP16 is a endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

Research area interests

Diseases associated with MMP16 include Osteochondrosis. Among its related pathways are Matrix Metalloproteinases and MicroRNAs in cancer.

Package form

liquid

Tested applications

Activation of progelatinase A; Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard

Other names

Membrane-Type 3 Matrix Metalloproteinase

Peptide sequence

L T G R K W Q H K H I T Y S I K N V T P K V G D P E T R K A I R R A F D V W Q N V T P L T F E E V P Y S E L E N G K R D V D I T I I F A S G F H G D S S P F D G E G G F L A H A Y F P G P G I G G D T H F D S D E P W T L G N P N H D G N D L F L V A V H E L G H A L G L E H S N D P T A I M A P F Y Q Y M E T D N F K L P N D D L Q G I Q K I Y G P P D K I P P P T R P L P T V P P H R

Available target modification

No

Expression system

E.coli

Product Subtype

protein fragment

Active form?

Yes

Tag

untagged

Contents

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 1 % glycerin, 0.1 % Triton X-100.

Protein purity

0.8

Molecular weight

23 kDa

UniProt number

P51512

Gene number

4325

Abbreviation

MMP16 (partial)

Full name

matrix metallopeptidase 16 (partial)

Other desciption

The catalytic domain of MT3-MMP is produced by activation of a recombinant soluble proform of MT3-MMP purified from E. coli.

Purification

Mentioned in the data sheet

PubMed citations

See the data sheet

Warnings

For Research Use only.

Shipping conditions

dry ice

Storage condition

Store at -70°C

Technical datasheet

Contact us to receive the datasheet

Source

Recombinants or rec. proteins

Group

recombinants