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MMP 17 (MT4-MMP) catalytic domain, His-tagged (Recombinant Protein)
from  biotez
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30 100 402 Catalog number

10 µg/ 50µl Size

340 € Price

More details

Protein type

Recombinant

Protein subtype

EC 3.4.24.-

Protein family

Matrix Metalloproteinases, matrixins

Protein description

MMP17 is a endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.

Research area interests

Among MMP17 related pathways are Matrix Metalloproteinases and Degradation of the extracellular matrix.

Package form

liquid

Tested applications

Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard

Other names

Membrane-Type 4 Matrix Metalloproteinase

Peptide sequence

Q A P A P T K W N K R N L S W R V R T F P R D S P L G H D T V R A L M Y Y A L R V W S D I A P L N F H E V A G S T A D I Q I D L S K A D H N D G Y P F D G P G G T V A H A F F P G H H H T A G D T H F D D D E A W T F R S S D A H G M D L F A V A V H E F G H A I G L S H V A A A H S I M R P Y Y Q G P V G D P L R Y G L P Y E D K V R V W Q L Y G V R E S V S P T A Q P E E P P L E H H H H H H

Available target modification

No

Expression system

E.coli

Product Subtype

protein fragment

Active form?

Yes

Tag

His-tagged

Contents

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 0.1% Triton X-100.

Protein purity

0.8

Molecular weight

24 kDa

UniProt number

Q9ULZ9

Gene number

4326

Abbreviation

MMP17 (partial)

Full name

matrix metallopeptidase 17 (partial)

Other desciption

The catalytic domain of human MT4-MMP is produced by tryptic activation of a recombinant soluble proform purified from E. coli periplasm.

Purification

Mentioned in the data sheet

PubMed citations

See the data sheet

Warnings

For Research Use only.

Shipping conditions

dry ice

Storage condition

Store at -70°C

Technical datasheet

Contact us to receive the datasheet

Conjugation

histidine

Source

Recombinants or rec. proteins

Group

recombinants