Matrix Metalloproteinases, matrixins
MMP17 is a endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
Among MMP17 related pathways are Matrix Metalloproteinases and Degradation of the extracellular matrix.
Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard
Membrane-Type 4 Matrix Metalloproteinase
Q A P A P T K W N K R N L S W R V R T F P R D S P L G H D T V R A L M Y Y A L R V W S D I A P L N F H E V A G S T A D I Q I D L S K A D H N D G Y P F D G P G G T V A H A F F P G H H H T A G D T H F D D D E A W T F R S S D A H G M D L F A V A V H E F G H A I G L S H V A A A H S I M R P Y Y Q G P V G D P L R Y G L P Y E D K V R V W Q L Y G V R E S V S P T A Q P E E P P L E H H H H H H
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 0.1% Triton X-100.
matrix metallopeptidase 17 (partial)
The catalytic domain of human MT4-MMP is produced by tryptic activation of a recombinant soluble proform purified from E. coli periplasm.
Mentioned in the data sheet
See the data sheet
For Research Use only.
Store at -70°C
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Recombinants or rec. proteins